# Running exome burden test

**URL:** <https://discuss.hail.is/t/running-exome-burden-test/1912>\
**Category:** Hail Query & hailctl\
**Created:** [February 11, 2021, 4:38pm UTC](https://discuss.hail.is/t/running-exome-burden-test/1912 "2021-02-11T16:38:57Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![Kaskere](https://yyz2.discourse-cdn.com/flex036/user_avatar/discuss.hail.is/kaskere/32/539_2.png) [@Kaskere](https://discuss.hail.is/u/Kaskere)\
**Post date:** [February 11, 2021, 4:38pm UTC](https://discuss.hail.is/t/running-exome-burden-test/1912/1 "2021-02-11T16:38:57Z")

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Hello,  
I am in urgent need to run rare variant burden test on GRCh38 exomes  
I found, that it is possible to use gnomAD cloud services instead of downloading entire file

I only found GRCh37 exome files. I can lift over them, but to my knowledge, liftover is not the best option

Therefore the question:is that possible to run rare variant test on GRCh38 exome VCFs, using gnomAD v.3.1 genomes as controls?

Thank you!