Sandwich corrected standard errors?

#1

What are the chances that HAIL at some point will include sandwich corrected SE’s for robust inference in dataset which contain family members?

Best,
Michel

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#2

Hi Michel,
This is something which I don’t expect to ever be super high priority for the development team, but that doesn’t mean Hail will never include a sandwich correction – in an open-source project, features arrive when someone adds them!

We do have a linear mixed regression method, which should account for family structure in a first-class way. Is there a particular reason that this model won’t work for your analysis?

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#3

Thought I would bring this back up as I have run into another use case for robust/Huber-White/sandwich standard errors recently. Specifically, they seem to be very helpful in combatting heteroscedasticity in the exposure/outcome relationship for GxE interaction tests (for example, see here).

Thanks!
Kenny

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