# SNV De novo calling tool for cohort research at scale

**URL:** <https://discuss.hail.is/t/snv-de-novo-calling-tool-for-cohort-research-at-scale/4251>\
**Category:** Feature Requests\
**Created:** [June 2, 2026, 3:55pm UTC](https://discuss.hail.is/t/snv-de-novo-calling-tool-for-cohort-research-at-scale/4251 "2026-06-02T15:55:38Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![Eliawad14](https://avatars.discourse-cdn.com/v4/letter/e/d6d6ee/32.png) [@Eliawad14](https://discuss.hail.is/u/Eliawad14)\
**Post date:** [June 2, 2026, 3:55pm UTC](https://discuss.hail.is/t/snv-de-novo-calling-tool-for-cohort-research-at-scale/4251/1 "2026-06-02T15:55:38Z")

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My name is Elias and I work in the Genetics Department at Baylor  
College of Medicine. I created an add on function to the Hail program  
that can process WGS/WES VCF files for De novo variants in a  
build-agnostic, pedigree-free manner for SNV calls. I have tested it  
at cohort scale and processed 2000 family quad files with one Slurm  
script using the function.

I will be publishing these methods and results but thought I would  
reach out to see if there was any interest in incorporating this tool  
into Hail itself.

Best  
Elias