Obtaining constraint scores from gnomad hail table data?

Hail Query & hailctl
1

Hello,

Pretty much the title. I have gnomad v2.1 hail table data and would like to know if I can extract the constraint scores from it.

2

By “gnomad v2.1 hail table data”, are you referring to the variants?

Constraint is stored separately from variant data and can be downloaded in Hail or TSV format from the URLs listed in the constraint section on the gnomAD downloads page.

3

Thanks for that, I had missed that somehow.

No constraint data is available for gnomAD v3/Liftover. While the scores are provided on gene basis, would the difference in transcripts change the scores? My data is on GRCh38 and was wondering if I could still go ahead and use the constraints data.