Hi @danielgoldstein , I will try with a much lower memory configuration first and will report back. I have 50’000 partitions, I’m following the tutorials from here: hgdp_tgp/tutorials at master · atgu/hgdp_tgp (github.com). I’ve ran into some performance issues and created a post a while back (if you want to check it out, it’s this one here Slow speed when using gnomadV3 callset - Hail Query & hailctl - Hail Discussion. Thanks for your help so far!