Implement Regenie

Feature Requests
1

Hi Hail team,

Regenie is for the gene/region-based burden test and it works on both quantitative and binary traits.
It would be very useful for whole-genome regression modeling. I would be very happy if Regenie could be used in Hail.

Mbatchou, J., Barnard, L., Backman, J. et al. Computationally efficient whole-genome regression for quantitative and binary traits. Nat Genet 53, 1097–1103 (2021). Computationally efficient whole-genome regression for quantitative and binary traits | Nature Genetics

https://rgcgithub.github.io/regenie/

Thanks,
minyoung

2

Hi!
A sidenote: You may be interested in GloWGR: Whole Genome Regression — Glow documentation

3

We are definitely aware of Regenie and it is something we are looking into adding support for, but don’t have any clear plans / timelines yet.

4

Thank you for your answer!